In New York City, bright but naive New Englander Anne Welles (Barbara Parkins) becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke (Paul Burke). Anne befriends up-and-coming singer Neely O'Hara (Patty Duke), whose dynamic talent threatens aging star Helen Lawson (Susan Hayward) ]and beautiful but talentless actress Jennifer North (Sharon Tate). The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.
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